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Targeting aging with urolithin A in humans: A systematic review

Hodzic Kuerec A, Lim XK, Khoo AL, Sandalova E, Guan L, Feng L, Maier AB
Ageing Research Reviews 2024 100:102406

Bibliography

PubMed
PMID 39002645
DOI
10.1016/j.arr.2024.102406
Funding
Andrea B. Maier reported financial support from the Lien Foundation.
Competing interests
The authors declared no other known competing financial interests or personal relationships.

Study snapshot

DesignSystematic review of human Urolithin A intervention studies
ModelHealthy human participants across five studies
Sample5 studies; 250 participants
InterventionUrolithin A 10-1,000 mg/day for 28 days to 4 months
Duration28 days to 4 months across included studies
EndpointsInflammatory markers; Mitochondrial gene expression; Autophagy and fatty-acid oxidation markers; Muscle strength and endurance; Physical function; Safety

What the study showed, in plain terms

This independent 2024 systematic review assembled the early human Urolithin A literature. It found signals for lower inflammation and changes in mitochondrial/autophagy-related markers plus some strength/endurance outcomes, but no consistent effect on anthropometrics, cardiovascular outcomes or broad physical function.

Key findings

Five human studies involving 250 participants were included.

Some inflammatory, mitochondrial, autophagy and fatty-acid-oxidation markers improved.

Strength/endurance signals were reported, while physical function and cardiovascular outcomes were not consistently improved.

Adverse events were generally mild or moderate and unrelated.

What this study can and cannot tell us

Only five studies were available.

Trials were small and short.

The evidence base was heterogeneous and several primary studies were industry-linked.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology