Tier 3 — preclinical
Oral Hyaluronic Acid Supplementation for the Treatment of Dry Eye Disease: A Pilot Study
Journal of Ophthalmology
2019
2019:5491626
Bibliography
- PubMed
- PMID 31662894
- PubMed Central
- PMC6778932
- Competing interests
- The authors declared no conflicts of interest.
Study snapshot
| Design | Prospective randomized controlled pilot trial |
|---|---|
| Model | Adults with dry eye disease |
| Sample | n=54 enrolled; 24 assigned to oral-HA study group |
| Intervention | Oral sodium hyaluronate 240 mg/day, 390 kDa, plus topical 0.15% HA versus topical 0.15% HA alone |
| Duration | 3 months |
| Endpoints | Ocular Surface Disease Index; Tear break-up time; Corneal fluorescein staining; Schirmer test |
What the study showed, in plain terms
Key findings
What this study can and cannot tell us
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- Hyaluronic Acid for Dry Eyes: Does an Oral Supplement Help?Oral hyaluronic acid has one small randomized dry-eye trial—but it was tested as an add-on to topical HA, not as a replacement...Read analysis
- Hyaluronic Acid Side Effects & Safety: What Human Studies ShowEvidence-based oral hyaluronic acid safety guide covering side effects, daily use, interactions, pregnancy, studied doses and the limits of long-term data.Read analysis
- Hyaluronic Acid Dosage: 60, 100, 120 or 200 mg?Evidence-based oral hyaluronic acid dosage guide covering 60, 100, 111, 120, 140, 200 and 240 mg doses used in human skin, joint,...Read analysis
- Hyaluronic Acid Supplements: Benefits, Dosage, Safety & Evidence (2026)Oral hyaluronic acid supplement evidence for skin, joints, dosage, safety, molecular weight and absorption—separated from serum, fillers and injections.Read analysis
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