Tier 3 — preclinical

Clinical effect of hyaluronic acid diet for dry skin - objective evaluation with microscopic skin surface analyzer

O Kajimoto, W Odanaka, W Sakamoto, K Yoshida, T Takahashi
J New Remedies & Clinics 2001 50(5):548-560

Bibliography

Study snapshot

DesignRandomized, double-blind, placebo-controlled clinical trial
ModelAdults with dry skin
Samplen=22
InterventionOral hyaluronic acid 240 mg/day, approximately 80 kDa, versus placebo
Duration6 weeks
EndpointsSkin moisture; Microscopic skin-surface analysis; Dry-skin condition

What the study showed, in plain terms

This early Japanese placebo-controlled trial tested 240 mg/day oral hyaluronic acid in 22 adults with dry skin for six weeks. Later reviews report improved skin moisture and dry-skin measures versus placebo. Because the original paper is an older Japanese-language source with limited modern indexing, it is preserved as lower-tier primary evidence rather than weighted like a recent large RCT.

Key findings

What this study can and cannot tell us

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology