Tier 4 — mechanistic

Pharmacokinetics and metabolism of apigenin in female and male rats after a single oral administration

Angéline Gradolatto, Jean-Philippe Basly, Raymond Berges, Caroline Teyssier, Marie-Christine Chagnon, Marie-Hélène Siess, Marie-Chantal Canivenc-Lavier
Drug Metabolism and Disposition 2005 33(1):49-54

Bibliography

PubMed
PMID 15466493
DOI
10.1124/dmd.104.000893
Funding
Supported by grants from the Conseil Régional de Bourgogne, Ministère de l’Environnement, and Institut National de la Recherche Agronomique.

Study snapshot

DesignIn vivo single-dose pharmacokinetic and metabolism study
ModelFemale and male rats across maturity groups
Sample
InterventionSingle oral administration of radiolabeled apigenin
Duration
EndpointsUrinary and fecal recovery; Tissue distribution; Blood kinetics; Glucuronide and sulfate metabolites; Sex differences in metabolism

What the study showed, in plain terms

This foundational animal study tracked radiolabeled apigenin after a single oral dose to map absorption, distribution, metabolism and elimination.

Key findings

Apigenin showed slow absorption and elimination in rats, broad metabolite formation and sex-related differences in the balance of glucuronide versus sulfate conjugates.

What this study can and cannot tell us

Rat pharmacokinetics cannot be directly converted into human supplement bioavailability or dosing. Later human studies are more directly relevant for exposure estimates.

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology