Tier 4 — mechanistic

Ingestion of an Oral Hyaluronan Solution Improves Skin Hydration, Wrinkle Reduction, Elasticity, and Skin Roughness: Results of a Clinical Study

Imke Göllner, Werner Voss, Ulrike von Hehn, Susanne Kammerer
Journal of Evidence-Based Complementary & Alternative Medicine 2017 22(4):816-823

Bibliography

PubMed
PMID 29228816
PubMed Central
PMC5871318
DOI
10.1177/2156587217743640

Study snapshot

DesignProspective uncontrolled practice study
Model20 healthy women aged 45–60
Samplen=20
InterventionRegulatpro Hyaluron oral HA preparation in a fermented whole-food concentrate with biotin, vitamin C, copper and zinc
Duration40 days
EndpointsSkin hydration; Elasticity; Skin roughness; Wrinkle depth; Tolerability

What the study showed, in plain terms

Skin hydration and elasticity increased while roughness and wrinkle depth decreased over 40 days in 20 women taking a multi-ingredient oral HA solution. With no placebo group and several co-ingredients, this is low-tier formulation evidence rather than proof of HA efficacy.

Key findings

What this study can and cannot tell us

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology