Tier 4 — mechanistic

Alterations in glycine metabolism in obesity and chronic metabolic diseases - an update on new advances

Alves A, Morio B
Current opinion in clinical nutrition and metabolic care 2023 26(1):50-54

Bibliography

PubMed
PMID 36542534
DOI
10.1097/mco.0000000000000883
Funding
Funding was not specified in the indexed abstract; the full funding disclosure has not been verified.
Competing interests
The accessible abstract does not establish the authors' competing interests; absence of a statement is not evidence of no conflicts.

Study snapshot

DesignNarrative review
ModelHuman and preclinical literature
SampleReview of newer obesity and metabolic-disease literature
InterventionGlycine availability, BCAA metabolism, weight loss and microbiota
DurationNot applicable; review
EndpointsCirculating glycine; Insulin resistance; Strategies to replenish glycine

What the study showed, in plain terms

This update emphasizes that glycine metabolism interacts with BCAA handling and weight loss. It explicitly leaves open whether dietary glycine effectively treats cardiometabolic disorders.

Key findings

  • Weight-loss strategies can replenish circulating glycine.
  • BCAA metabolism and microbiota may influence glycine availability.

What this study can and cannot tell us

Narrative evidence synthesis rather than a treatment trial.

Restoring a circulating amino-acid concentration is not equivalent to improving clinical outcomes.

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Glycine metabolism in animals and humans: implications for nutrition and health
Wang W et al. · Amino acids · 2013
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Glycine Metabolism and Its Alterations in Obesity and Metabolic Diseases
Alves A et al. · Nutrients · 2019
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Insulin resistance and glycine metabolism in humans
Adeva-Andany M et al. · Amino acids · 2018
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Glycine as a conditionally essential amino acid and its relationship to l-serine
Holeček M et al. · Metabolism: clinical and experimental · 2025
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A weak link in metabolism: the metabolic capacity for glycine biosynthesis does not satisfy the need for collagen synthesis
Meléndez-Hevia E et al. · Journal of biosciences · 2009

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction