Tier 4 — mechanistic

Plasma Glycine and Risk of Acute Myocardial Infarction in Patients With Suspected Stable Angina Pectoris

Ding Y, Svingen GF, Pedersen ER, Gregory JF, Ueland PM, Tell GS, Nygård OK
Journal of the American Heart Association 2015 5(1):e002621

Bibliography

PubMed
PMID 26722126
PubMed Central
PMC4859380
DOI
10.1161/jaha.115.002621
Funding
Support from the University of Bergen, Haukeland University Hospital, Western Norway Health Authority and a vitamin B12 research foundation.
Competing interests
The authors reported no disclosures.

Study snapshot

DesignHuman observational study
ModelAdult humans
Sample4,109 adults investigated for suspected stable angina; 616 myocardial infarctions during follow-up
InterventionBaseline plasma glycine measurement and linkage to subsequent clinical events
DurationMedian 7.4 years follow-up
EndpointsAcute myocardial infarction; Lipid-related effect modification

What the study showed, in plain terms

Higher plasma glycine was associated with lower subsequent myocardial-infarction risk in adults referred for coronary assessment. This is a prognostic association, not a test of supplementation.

Key findings

  • The cohort recorded 616 infarctions.
  • Associations varied with lipid and apolipoprotein levels.

What this study can and cannot tell us

Residual confounding, underlying disease and metabolic health may influence glycine.

The study does not show that glycine supplements prevent heart attacks.

Related papers in the corpus

Tier 3
Exploring the Role of Glycine Metabolism in Coronary Artery Disease: Insights from Human Genetics and Mouse Models
Biswas S et al. · Nutrients · 2025
Tier 2
Oral administration of glycine in the prevention of restenosis after coronary angioplasty. A double blind placebo controlled randomized feasibility trial evaluating safety and efficacy of glycine in the prevention of restenosis after angioplasty
Khan M et al. · Acute cardiac care · 2006
Tier 4
Assessing the causal association of glycine with risk of cardio-metabolic diseases
Wittemans LBL et al. · Nature communications · 2019
Tier 4
Genetic Determinants of Circulating Glycine Levels and Risk of Coronary Artery Disease
Jia Q et al. · Journal of the American Heart Association · 2019
Tier 4
The association of genetically determined serum glycine with cardiovascular risk in East Asians
Chang X et al. · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2021
Tier 4
Interplay Between Plasma Glycine and Branched-Chain Amino Acids Contributes to the Development of Hypertension and Coronary Heart Disease
Dziedzic M et al. · Hypertension (Dallas, Tex. : 1979) · 2024

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction