Tier 3 — preclinical
The sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
2015
40(6):1405-1416
Bibliography
- PubMed
- PMID 25533534
- PubMed Central
- PMC4397399
- Funding
- Ajinomoto funded the work of N. Sakai, M. Okuro and S. Nishino, according to the funding and disclosure statement.
- Competing interests
- The disclosure identifies four authors as Ajinomoto employees and three authors as recipients of Ajinomoto funding.
Study snapshot
| Design | Controlled animal intervention with mechanistic experiments |
|---|---|
| Model | Rats; oral and intracranial interventions |
| Sample | Multiple rat experiments; group sizes vary by experiment |
| Intervention | Oral glycine and targeted brain injections, with receptor antagonists and SCN ablation |
| Duration | Acute experiments |
| Endpoints | NREM sleep latency; Core temperature; Cutaneous blood flow; NMDA signaling |
What the study showed, in plain terms
Key findings
What this study can and cannot tell us
Editorial review
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