Tier 4 — mechanistic

GetHealthy-OA: A Biopsychosocial Treatment Approach to Improve Pain and Function for Patients With Comorbid Knee Osteoarthritis, Obesity, and Depression

University of Kentucky study team
ClinicalTrials.gov trial registry record 2022

Bibliography

Trial registry
View on ClinicalTrials.gov Registered trial — results not yet published in a peer-reviewed journal.
Funding
The trial was withdrawn because of lack of funding.
Competing interests
Not reported in the registry record.

Study snapshot

DesignPlanned Phase 2/3 randomized study of a biopsychosocial program incorporating fisetin.
ModelAdults with knee osteoarthritis plus obesity and depression.
Sample0 actual participants; 120 were planned.
InterventionPlanned intermittent oral fisetin for two days, followed by a 28-day interval and another two-day course, delivered within a broader mind-body/biopsychosocial program.
DurationPlanned multi-week program with clinical follow-up.
EndpointsKnee pain; Physical function; PROMIS pain interference; Daily step count; Inflammatory markers

What the study showed, in plain terms

GetHealthy-OA planned to study fisetin inside a broader behavioral and mind-body program for people with knee osteoarthritis, obesity and depression.

The trial was withdrawn because of lack of funding and enrolled no participants. It therefore provides no evidence that fisetin or the combined program improves osteoarthritis outcomes.

Key findings

  • Planned enrollment was 120.
  • Fisetin was only one component of a broader intervention.
  • The trial was withdrawn before generating outcome data.

What this study can and cannot tell us

  • Zero enrollment and no results.
  • Multimodal design would have limited attribution to fisetin even if completed.
  • Planned protocol does not validate the dosing schedule.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology