Tier 1 — highest

Effects of Vitamin D, Omega-3 Fatty Acids and a Home Exercise Program on Prevention of Pre-Frailty in Older Adults: The DO-HEALTH Randomized Clinical Trial

M Gagesch, M Wieczorek, B Vellas, R W Kressig, R Rizzoli, J Kanis, W C Willett, A Egli, W Lang, E J Orav, H A Bischoff-Ferrari
The Journal of frailty & aging 2023 12(1):71-77

Bibliography

PubMed
PMID 36629088
DOI
10.14283/jfa.2022.48
Trial registry
View on ClinicalTrials.gov Registered trial — results not yet published in a peer-reviewed journal.
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
The authors report no relevant competing interests.

Study snapshot

DesignSecondary frailty analysis of the randomized DO-HEALTH trial
ModelHuman participants
Sample1,137 participants classified as robust at baseline
InterventionD3 2,000 IU/day, omega-3 1 g/day and/or home exercise
DurationApproximately 3 years
EndpointsIncident pre-frailty; Incident frailty

What the study showed, in plain terms

This publication examines incident pre-frailty, incident frailty. Study population or evidence base: 1,137 participants classified as robust at baseline. Intervention or exposure: D3 2,000 IU/day, omega-3 1 g/day and/or home exercise.

Key findings

The three interventions together reduced the odds of becoming pre-frail. Individual interventions were not significant, and no regimen significantly reduced incident frailty.

What this study can and cannot tell us

A secondary analysis with few frailty cases and a combination-specific result. The findings do not isolate an independent vitamin D effect.

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