Tier 1 — highest

Effect of Vitamin D Supplementation, Omega-3 Fatty Acid Supplementation, or a Strength-Training Exercise Program on Clinical Outcomes in Older Adults: The DO-HEALTH Randomized Clinical Trial

Heike A Bischoff-Ferrari, Bruno Vellas, René Rizzoli, Reto W Kressig, José A P da Silva, Michael Blauth, David T Felson, Eugene V McCloskey, Bernhard Watzl, Lorenz C Hofbauer, Dieter Felsenberg, Walter C Willett, Bess Dawson-Hughes, JoAnn E Manson, Uwe Siebert, Robert Theiler, Hannes B Staehelin, Caroline de Godoi Rezende Costa Molino, Patricia O Chocano-Bedoya, Lauren A Abderhalden, Andreas Egli, John A Kanis, Endel J Orav, DO-HEALTH Research Group
JAMA 2020 324(18):1855-1868

Bibliography

PubMed
PMID 33170239
PubMed Central
PMC7656284
DOI
10.1001/jama.2020.16909
Trial registry
View on ClinicalTrials.gov Registered trial — results not yet published in a peer-reviewed journal.
Funding
Support is recorded from European Commission Seventh Framework Programme, Medical Research Council, NIAMS NIH HHS. See the original publication for grant and material-support details.
Competing interests
The source discloses financial, employment, advisory or material-support relationships involving Pharmavite, Nestlé, Pfizer, Roche. See the publication for the authors and nature of each relationship.

Study snapshot

DesignRandomized controlled clinical trial
ModelHuman participants
Sample2,157 generally healthy adults aged 70+
InterventionD3 2,000 IU/day, omega-3 1 g/day and/or home strength exercise in a factorial design
Duration3 years
EndpointsBlood pressure; Physical performance; Cognition; Nonvertebral fractures; Infections

What the study showed, in plain terms

This publication examines blood pressure, physical performance, cognition, nonvertebral fractures, infections. Study population or evidence base: 2,157 generally healthy adults aged 70+. Intervention or exposure: D3 2,000 IU/day, omega-3 1 g/day and/or home strength exercise in a factorial design.

Key findings

The individual interventions and combinations did not significantly improve the six primary outcomes under the trial's prespecified multiple-testing threshold.

What this study can and cannot tell us

Generally healthy, mobile older adults may differ from frail or deficient patients. Subsequent DO-HEALTH publications analyze additional outcomes in this same parent trial.

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