Tier 3 — preclinical

Collagen Peptides, in Association with Vitamin C, Sodium Hyaluronate, Manganese and Copper, as Part of the Rehabilitation Project in the Treatment of Chronic Low Back Pain

Giacomo Farì, Dario Santagati, Giovanni Pignatelli, Venera Scacco, Domenico Renna, Giuseppe Cascarano, Francesco Vendola, Francesco Paolo Bianchi, Pietro Fiore, Maurizio Ranieri, Marisa Megna
Endocrine, Metabolic & Immune Disorders - Drug Targets 2022 22(1):108-115

Bibliography

PubMed
PMID 33568038
DOI
10.2174/1871530321666210210153619

Study snapshot

DesignRandomized controlled rehabilitation study
ModelAdults with osteoarthritis-related chronic low back pain
Samplen=60
InterventionMcKenzie kinesitherapy alone versus same rehabilitation plus daily collagen peptides with vitamin C 80 mg, sodium hyaluronate 50 mg (about 46 mg HA), manganese 1 mg and copper 0.5 mg
Duration3 weeks treatment with follow-up 6 weeks later
EndpointsVAS pain; Oswestry Disability Index; SF-12 physical and mental components

What the study showed, in plain terms

Both rehabilitation groups improved, but the group receiving the multi-ingredient oral supplement improved more and maintained several gains at follow-up. HA was only one component of a collagen/vitamin/mineral formula, so this study cannot support HA-specific low-back-pain claims.

Key findings

What this study can and cannot tell us

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology