Tier 4 — mechanistic

Apigenin glycosides from green pepper enhance longevity and stress resistance in Caenorhabditis elegans

Abdeen E Elkhedir, Aamir Iqbal, Daniel Zogona, Hammad Hamed Mohammed, Ayesha Murtaza, Xiaoyun Xu
Nutrition Research 2022 102:23-34

Bibliography

PubMed
PMID 35366456
DOI
10.1016/j.nutres.2022.02.003

Study snapshot

DesignIn vivo model-organism lifespan study
ModelCaenorhabditis elegans
Sample
InterventionApigenin glycoside-rich fraction from Xiaomila green pepper
Duration
EndpointsMean lifespan; Oxidative-stress resistance; ROS; DAF-16 and SKN-1 nuclear translocation; sir-2.1 signaling

What the study showed, in plain terms

This worm study tested apigenin glycosides from green pepper for effects on lifespan and stress resistance.

Key findings

The apigenin-glycoside fraction increased mean lifespan by about 23.9%, reduced ROS and required several conserved stress-response pathways including DAF-16, SKN-1 and SIR-2.1.

What this study can and cannot tell us

The intervention was a plant-derived glycoside fraction in worms, not isolated apigenin in humans. Lifespan effects cannot be directly translated to people.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology