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Calcium and Vitamin D Supplementation with and Without Collagen on Bone Density and Skin Elasticity in Menopausal Women-A Randomized Controlled Study

Acharaporn Duangjai
Clinical Practice 2025 15(9):168

Bibliography

PubMed
PMID 41002783
DOI
10.3390/clinpract15090168
Funding
Supported by the Program Management Unit for Competitiveness (PMUC), grant C02F660120.
Competing interests
Authors declared no conflicts of interest.

Study snapshot

DesignFour-arm randomized controlled study comparing collagen, calcium/vitamin D, their combination and placebo
ModelMenopausal women
Sample80 menopausal women randomized equally to four groups (n=20 per arm).
Intervention5 g/day marine collagen alone, calcium 1000 mg + D3 400 IU, both, or placebo
Duration6 months
EndpointsSkin hydration and elasticity; Hair shedding; Bone turnover markers; Body composition; Safety labs

What the study showed, in plain terms

A four-arm study reported some skin and hair-related improvements after marine collagen-containing interventions but no significant group changes in bone turnover markers or body composition.

Key findings

The combined collagen/calcium/D arm improved hydration and elasticity in reported analyses; the collagen-only arm improved elasticity versus its own baseline. No significant differences in bone biomarkers among groups.

What this study can and cannot tell us

This six-month trial tested a fish-derived collagen preparation, not a bovine DoNotAge product. It used four arms (placebo, calcium plus vitamin D, collagen, and the combination), so interpretation should prioritize prespecified between-group contrasts rather than within-group change alone. No significant group differences were reported for body composition or the measured bone-turnover biomarkers, so the study does not establish a bone-density benefit from collagen.

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology