Tier 2 — strong

The Efficacy and Safety of CollaSel Pro Hydrolyzed Collagen Peptide Supplementation without Addons in Improving Skin Health in Adult Females: A Double Blind, Randomized, Placebo-Controlled Clinical Study Using Biophysical and Skin Imaging Techniques

Devrim Demir-Dora, Umut Ozsoy, Yilmaz Yildirim, Oguz Yilmaz, Peri Aytac, Beste Yilmaz, Emel Dogan Kurtoglu, Ayse Akman, Selim Tezman, Huseyin Serhat Inaloz, Aydin Erenmemisoglu
Journal of Clinical Medicine 2024 13(18):5370

Bibliography

PubMed
PMID 39336856
PubMed Central
PMC11432272
DOI
10.3390/jcm13185370
Competing interests
The author list includes representatives of the CollaSel product supplier and a contract research organization; assess funding and competing interests in the full paper.

Study snapshot

DesignEight-week randomized double-blind placebo-controlled clinical study.
Model112 adult women; 57 collagen and 55 placebo.
Sample112 randomized.
Intervention10 g/day CollaSel Pro hydrolyzed collagen versus 10 g/day maltodextrin placebo; no additional active ingredients.
Duration8 weeks
EndpointsSkin elasticity; Skin hydration; Skin roughness; Facial soft-tissue sagging; Safety

What the study showed, in plain terms

An eight-week study in 112 women reported improved instrumental skin hydration and elasticity with 10 g/day CollaSel Pro collagen compared with placebo. The trial is useful because collagen was tested without additional actives, but manufacturer involvement and proprietary peptide differences limit generalization.

Key findings

The paper reported favorable between-group skin hydration and elasticity measures at week eight; roughness measures were also reported as favorable in the authors' analysis.

What this study can and cannot tell us

Short follow-up, female-only population, proprietary CollaSel preparation and author affiliations with manufacturer/supplier. A positive individual trial does not settle the contradictory high-quality/funding-sensitive skin meta-analyses or establish DoNotAge-specific efficacy.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology