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Effect of dietary supplementation with collagen hydrolysates on bone metabolism of postmenopausal women with low mineral density

Florencia Cúneo, Lúcia Costa-Paiva, Aarão Mendes Pinto-Neto, Sirlei Siani Morais, Jaime Amaya-Farfan
Maturitas 2010 65(3):253–257

Bibliography

PubMed
PMID 19892499
DOI
10.1016/j.maturitas.2009.10.002

Study snapshot

Design24-week randomized double-blind placebo-controlled trial.
ModelPostmenopausal women with low bone mineral density.
Sample71; 36 collagen and 35 placebo.
Intervention10 g/day collagen hydrolysate versus placebo.
Duration24 weeks
EndpointsCTX bone resorption marker; Osteocalcin; Bone-specific alkaline phosphatase

What the study showed, in plain terms

A 24-week randomized study in 71 postmenopausal women with low bone density found no between-group benefit from 10 g/day collagen hydrolysate on measured markers of bone turnover. This negative study should be presented alongside later positive studies of specific proprietary collagen peptides.

Key findings

Both collagen and placebo groups had changes in some biomarkers over time, but between-group analyses showed no effect of collagen on biochemical bone remodeling markers.

What this study can and cannot tell us

Did not establish effects on fracture risk or long-term bone mineral density. Participants often had inadequate calcium intake, and trial size/follow-up may limit detection of small changes. It remains valid counter-evidence to a blanket collagen-bone-benefit claim.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology