Tier 2 — strong

Oral administration of hydrolyzed collagen alleviates pain and enhances functionality in knee osteoarthritis: Results from a randomized, double-blind, placebo-controlled study

Juan Antonio Carrillo-Norte, Guillermo Gervasini-Rodríguez, María Ángeles Santiago-Triviño, Virginio García-López, Rafael Guerrero-Bonmatty
Contemporary Clinical Trials Communications 2025 43:101424

Bibliography

PubMed
PMID 39839727
PubMed Central
PMC11745964
DOI
10.1016/j.conctc.2024.101424

Study snapshot

DesignSix-month randomized double-blind placebo-controlled trial.
ModelAdults aged 30–81 years, Kellgren–Lawrence grade II–III knee OA.
Sample120 randomized; 60 active and 60 placebo; all completed.
Intervention10 g/day 1–3 kDa bovine type I/III collagen peptides plus 80 mg vitamin C (COLLinstant) versus placebo.
Duration6 months
EndpointsVAS pain; Lequesne algofunctional index; CRP; ESR; Tolerability

What the study showed, in plain terms

This trial reported less knee pain and better function with a 10 g/day collagen-peptide supplement containing 80 mg vitamin C over six months in 120 adults with moderate knee osteoarthritis. Because the intervention combined ingredients and used the proprietary COLLinstant preparation, the result is not an exact-product trial of DoNotAge collagen powder.

Key findings

The active group improved versus placebo on VAS pain, Lequesne function, CRP and ESR at six months (reported p<0.001); no adverse effects were reported.

What this study can and cannot tell us

The formulation includes vitamin C, so collagen-only effects are not isolated. Results concern symptom and biomarker outcomes, not cartilage regeneration or prevention of joint replacement. Findings cannot be transferred automatically to DoNotAge's generic bovine peptides.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology