Tier 4 — mechanistic

Berberine Phospholipid Is an Effective Insulin Sensitizer and Improves Metabolic and Hormonal Disorders in Women with Polycystic Ovary Syndrome: A One-Group Pretest-Post-Test Explanatory Study

Rondanelli M, Riva A, Petrangolini G, Allegrini P, Giacosa A, Fazia T, Bernardinelli L, Gasparri C, Peroni G, Perna S
Nutrients 2021 13(10):3665

Bibliography

PubMed
PMID 34684666
PubMed Central
PMC8538182
DOI
10.3390/nu13103665
Funding
The authors reported no external funding.
Competing interests
A complete competing-interest declaration was not available in the accessible source; no absence of conflicts is inferred.

Study snapshot

DesignSingle-group before-and-after formulation study
ModelHuman participants; see population
Sample12 women
InterventionBerberine phospholipid formulation, two 550-mg tablets/day
Duration60 days
EndpointsMetabolic and hormonal measures; Menstrual or fertility outcomes; Tolerability

What the study showed, in plain terms

An uncontrolled formulation study reported changes in insulin resistance, inflammation, hormones and acne measures.

Key findings

  • An uncontrolled formulation study reported changes in insulin resistance, inflammation, hormones and acne measures.

What this study can and cannot tell us

Twelve participants, no control arm and many endpoints. Formulation mass is not isolated berberine mass.

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Editorial review

Reviewed by the Biohack Blueprint research team

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology