Tier 3 — preclinical
Safety of Hyaluronan 35 in Healthy Human Subjects: A Pilot Study
Nutrients
2019
11(5):1135
Bibliography
- PubMed
- PMID 31121841
- PubMed Central
- PMC6566413
- Trial registry
- View on ClinicalTrials.gov Registered trial — results not yet published in a peer-reviewed journal.
- Funding
- Major support from NIH P01 HL107417-S1 with additional NIH grants and a Mikati Foundation grant.
- Competing interests
- The paper reports that funders had no role in study design, data collection, analysis, interpretation, writing or publication decisions.
Study snapshot
| Design | Prospective open-label human safety and tolerability pilot |
|---|---|
| Model | Healthy adults |
| Sample | n=20 |
| Intervention | Pharmaceutical-grade 35 kDa sodium hyaluronate 140 mg/day orally |
| Duration | 7 days dosing; follow-up to day 28 |
| Endpoints | Adverse events; Clinical chemistry; Metabolic function; Gut permeability; Stool microbiome composition |
What the study showed, in plain terms
Key findings
What this study can and cannot tell us
Citation network
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