Tier 3 — preclinical

Apigenin: A Bioflavonoid with a Promising Role in Disease Prevention and Treatment

Khaled S. Allemailem, Ahmad Almatroudi, Hajed Obaid A. Alharbi, Naif AlSuhaymi, Mahdi H. Alsugoor, Fahad M. Aldakheel, Amjad Ali Khan, Arshad Husain Rahmani
Biomedicines 2024 12(6):1353

Bibliography

PubMed
PMID 38927560
PubMed Central
PMC11202028
DOI
10.3390/biomedicines12061353

Study snapshot

DesignNarrative review
ModelPublished apigenin literature
Sample
Intervention
Duration
Endpoints

What the study showed, in plain terms

This broad review surveys apigenin research across inflammation, oxidative stress, metabolic disease, neurological disease, cancer and formulation science.

Key findings

Recurring experimental themes include anti-inflammatory signaling, oxidative-stress modulation, apoptosis and cell-cycle effects in cancer models, and poor oral bioavailability.

What this study can and cannot tell us

Many benefits summarized come from cells or animals. The review itself calls for more work on mechanism, safety and efficacy.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology