Tier 2 — strong

Role of Magnesium in Vitamin D Activation and Function

Anne Marie Uwitonze, Mohammed S Razzaque

The Journal of the American Osteopathic Association 2018 118(3):181-189

Bibliography

PubMed: PMID 29480918
DOI: 10.7556/jaoa.2018.037
Funding: Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests: A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

Design	Narrative clinical and physiological review
Model	Human evidence synthesis
Sample	Review of multiple sources; no new trial cohort
Intervention	Dietary and supplemental magnesium in relation to vitamin D metabolism
Duration	Not applicable to a narrative review
Endpoints	Vitamin D activation and metabolism; Magnesium-dependent enzyme function

What the study showed, in plain terms

This publication examines vitamin d activation and metabolism, magnesium-dependent enzyme function. Study population or evidence base: Review of multiple sources; no new trial cohort. Intervention or exposure: Dietary and supplemental magnesium in relation to vitamin D metabolism.

Key findings

The review explains magnesium's role as a cofactor in vitamin D metabolism and supports maintaining adequate magnesium intake.

What this study can and cannot tell us

Mechanistic and narrative evidence does not show that everyone using vitamin D needs a magnesium supplement or that one specific combination prevents disease.

Tier 2

Magnesium: Are We Consuming Enough?

Mohammed S Razzaque et al. · Nutrients · 2018

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified 17 October 2026

Biohack Blueprint Research