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Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7

Leon J Schurgers, Kirsten J F Teunissen, Karly Hamulyák, Marjo H J Knapen, Hogne Vik, Cees Vermeer
Blood 2007 109(8):3279-83

Bibliography

PubMed
PMID 17158229
DOI
10.1182/blood-2006-08-040709
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignComparative human pharmacokinetic and biomarker study
ModelHuman participants
SampleHealthy adult volunteers; several linked absorption and supplementation experiments
InterventionVitamin K1 compared with natto-derived MK-7
DurationAcute absorption and repeated supplementation experiments
EndpointsCirculating vitamin K; Osteocalcin carboxylation; Anticoagulant sensitivity

What the study showed, in plain terms

This publication examines circulating vitamin k, osteocalcin carboxylation, anticoagulant sensitivity. Study population or evidence base: Healthy adult volunteers; several linked absorption and supplementation experiments. Intervention or exposure: Vitamin K1 compared with natto-derived MK-7.

Key findings

MK-7 persisted longer in circulation and accumulated more during repeated intake than K1. It also produced more sustained osteocalcin carboxylation.

What this study can and cannot tell us

Pharmacokinetic and biochemical outcomes do not demonstrate fewer fractures or cardiovascular events. MK-7 can interfere with vitamin K antagonist therapy.

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