Sabrina Schroeder, Sebastian J Hofer, Andreas Zimmermann, Raimund Pechlaner, Christopher Dammbrueck, Tobias Pendl, G Mark Marcello, Viktoria Pogatschnigg, Martina Bergmann, Melanie Müller, Verena Gschiel, Selena Ristic, Jelena Tadic, Keiko Iwata, Gesa Richter, Aitak Farzi, Muammer Üçal, Ute Schäfer, Michael Poglitsch, Philipp Royer, Ronald Mekis, Marlene Agreiter, Regine C Tölle, Péter Sótonyi, Johann Willeit, Barbara Mairhofer, Helga Niederkofler, Irmgard Pallhuber, Gregorio Rungger, Herbert Tilg, Michaela Defrancesco, Josef Marksteiner, Frank Sinner, Christoph Magnes, Thomas R Pieber, Peter Holzer, Guido Kroemer, Didac Carmona-Gutierrez, Luca Scorrano, Jörn Dengjel, Tobias Madl, Simon Sedej, Stephan J Sigrist, Bence Rácz, Stefan Kiechl, Tobias Eisenberg, Frank Madeo
F. Madeo, S.J. Sigrist and D. Carmona-Gutierrez disclosed equity interests in The Longevity Labs; T. Eisenberg disclosed equity and paid consultancy; additional author commercial relationships were disclosed.
Study snapshot
Design
Translational preclinical experiments plus prospective human observational analysis
Model
Aged mice, Drosophila and community-dwelling humans
Sample
Multiple model-organism cohorts plus prospective human observational data
Intervention
Dietary spermidine in animal models; estimated dietary spermidine intake in humans
Duration
Model-specific experimental durations plus prospective human follow-up; varies by analysis
This influential translational paper linked spermidine to improved cognition and mitochondrial function in animal models and reported prospective human data associating higher dietary spermidine intake with lower risk of cognitive impairment.
Key findings
The work provides a mechanistic bridge from autophagy/mitophagy to brain aging and a supportive human dietary association. It does not prove that spermidine supplements improve cognition in people.
What this study can and cannot tell us
The human component was observational, while the causal intervention experiments were performed in animals. Dietary spermidine estimates may reflect broader dietary patterns. Several authors disclosed equity or consultancy interests in The Longevity Labs.
