Tier 1 — highest

The effect of vitamin D supplementation on cancer incidence in the randomised controlled D-Health Trial: Implications for policy and practice

Rachel E Neale, Dallas R English, Donald Sa McLeod, Bruce K Armstrong, Catherine Baxter, Briony Duarte Romero, Peter R Ebeling, Gunter Hartel, Jolieke C van der Pols, Alison J Venn, Penelope M Webb, David C Whiteman, Mary Waterhouse
The Journal of steroid biochemistry and molecular biology 2025 250:106738

Bibliography

PubMed
PMID 40096917
DOI
10.1016/j.jsbmb.2025.106738
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
The source discloses financial, employment, advisory or material-support relationships involving Pfizer. See the publication for the authors and nature of each relationship.

Study snapshot

DesignCancer-incidence analysis of the randomized D-Health trial
ModelHuman participants
Sample21,308 older adults included in registry-linked analysis
InterventionVitamin D3 60,000 IU monthly or placebo
DurationUp to 5 years
EndpointsOverall cancer incidence; Selected site-specific cancers

What the study showed, in plain terms

This publication examines overall cancer incidence, selected site-specific cancers. Study population or evidence base: 21,308 older adults included in registry-linked analysis. Intervention or exposure: Vitamin D3 60,000 IU monthly or placebo.

Key findings

Vitamin D did not significantly change overall cancer incidence or the examined site-specific cancer outcomes.

What this study can and cannot tell us

An incidence analysis does not directly determine survival after a cancer diagnosis. This report uses the same D-Health participants as other outcome publications.

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