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Creatine monohydrate for lean mass, strength, and bone density in postmenopausal women: a systematic review and meta-analysis

Siavash Naddafha, Jose Antonio, Richard B Kreider, Jeffrey R Stout
J Int Soc Sports Nutr 2026 23(1):2668435

Bibliography

PubMed
PMID 42141930
PubMed Central
PMC13182165
Funding
The review received no external funding. The paper thanks Alzchem for supporting the remaining article-processing charge after a publisher waiver.
Competing interests
Authors declared no conflict related to the work; Richard B. Kreider disclosed chairing the Alzchem-supported Creatine for Health Scientific Advisory Board, and Jose Antonio disclosed ISSN leadership; the ISSN occasionally receives funding from creatine companies.

Study snapshot

DesignSystematic review and meta-analysis
ModelHuman
Sample7 randomized controlled trials; 608 randomized participants
InterventionCreatine monohydrate, commonly with resistance training, versus placebo/control
DurationVaried by included trial
EndpointsLean mass; Muscle strength; Bone mineral density

What the study showed, in plain terms

Recent meta-analysis focused specifically on postmenopausal women and clinically relevant muscle, strength and bone outcomes.

Key findings

The pooled evidence suggested modest gains in lean mass and leg-press strength, particularly in protocols using at least 5 g/day alongside resistance training; overall bone-mineral-density effects were not clearly improved.

What this study can and cannot tell us

Only seven trials, varied dosing and training protocols, and limited evidence for bone outcomes; results should not be generalized to all women or to creatine without exercise.

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