Tier 2 — strong

Taking vitamin D with the largest meal improves absorption and results in higher serum levels of 25-hydroxyvitamin D

Guy B Mulligan, Angelo Licata
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2010 25(4):928-30

Bibliography

PubMed
PMID 20200983
DOI
10.1002/jbmr.67
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignProspective, uncontrolled meal-timing cohort study
ModelHuman participants
Sample17 clinic patients with an inadequate response to vitamin D treatment
InterventionUsual prescribed vitamin D dose moved to the largest meal
Duration2–3 months
EndpointsSerum 25(OH)D

What the study showed, in plain terms

This publication examines serum 25(oh)d. Study population or evidence base: 17 clinic patients with an inadequate response to vitamin D treatment. Intervention or exposure: Usual prescribed vitamin D dose moved to the largest meal.

Key findings

Vitamin D concentrations increased after patients began taking their existing supplement with their largest meal.

What this study can and cannot tell us

No randomized control group and a small referral-clinic sample. Improved adherence, regression to the mean or other factors could contribute; the finding does not establish the best clock time.

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