Tier 3 — preclinical

The role of cellular senescence in ageing and endocrine disease

Khosla S, Farr JN, Tchkonia T, Kirkland JL
Nature Reviews Endocrinology 2020 16(5):263-275

Bibliography

PubMed
PMID 32161396
DOI
10.1038/s41574-020-0335-y
Funding
Not stated in the available abstract.
Competing interests
Not stated in the available abstract.

Study snapshot

DesignNarrative review
ModelMixed: preclinical mechanism plus early-phase human trial context
SampleNot applicable (review)
InterventionNot applicable (review of senescence/senolytic literature)
DurationNot applicable (review)
EndpointsCellular senescence mechanisms; Senolytic/SASP-inhibitor approaches; Endocrine and age-related disease associations

What the study showed, in plain terms

This review explains how senescent cells accumulate with age and contribute to age-related diseases, including endocrine conditions such as osteoporosis and type 2 diabetes. It covers senolytic drugs that clear these cells and SASP inhibitors that quiet their inflammatory signalling, noting that proof-of-concept human trials were just beginning at the time of writing.

Key findings

Cellular senescence has a causative role in multiple age-related diseases, and considerable preclinical evidence supports senolytic and SASP-inhibitor approaches, with proof-of-concept human trials beginning for several endocrine and non-endocrine diseases at the time of publication. The review covers general mechanisms and disease associations rather than skin/dermal senescence specifically.

What this study can and cannot tell us

General narrative review, not specific to dermatology or skin ageing. Cite for the general cellular-senescence-drives-ageing mechanism, not as direct evidence of dermal senescence intervention.

Citation network

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Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology