Tier 2 — strong

Increased nitrate intake from beetroot juice over 4 weeks affects nitrate metabolism, but not vascular function or blood pressure in older adults with hypertension

Rebeka Fejes, Martin Lutnik, Stefan Weisshaar, Nina Pilat, Karl-Heinz Wagner, Hans-Peter Stüger, Jonathan M Peake, Richard J Woodman, Kevin D Croft, Catherine P Bondonno, Jonathan M Hodgson, Michael Wolzt, Oliver Neubauer
Food & Function 2024 15(8):4065–4078

Bibliography

PubMed
PMID 38546454
PubMed Central
PMC11034575
Funding
Austrian Science Fund (FWF), Clinical Research KLIF grant KLI 858, granted to Oliver Neubauer; grant supported Neubauer and Fejes salaries partially and fully, respectively.
Competing interests
Authors declare no conflicts of interest (RSC article).

Study snapshot

DesignRandomized placebo-controlled crossover study
ModelOlder adults aged 56–71 with treated hypertension
Sample15 participants
InterventionSingle ~400 mg nitrate beetroot dose and four weeks of two ~400 mg daily nitrate doses versus nitrate-depleted beetroot placebo
DurationAcute 3-hour and 4-week interventions
EndpointsBlood pressure; Vascular function; Nitrate and nitrite metabolism

What the study showed, in plain terms

In older adults whose hypertension was treated, beetroot juice altered nitrate metabolism but did not improve vascular function or blood pressure over four weeks.

Key findings

Despite the expected rise in nitrate-related biomarkers, the measured vascular function and blood-pressure endpoints did not improve compared with placebo.

What this study can and cannot tell us

Small sample of treated older hypertensive adults; important null result, not proof dietary nitrate never benefits any other population.

Citation network

Articles citing this research paper

2 articles

Biohack Blueprint analyses that reference this study in their evidence base.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified