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Absence of an effect of high nitrate intake from beetroot juice on blood pressure in treated hypertensive individuals: a randomized controlled trial

Catherine P Bondonno, Alex H Liu, Kevin D Croft, Natalie C Ward, Sujata Shinde, Yuben Moodley, Jon O Lundberg, Ian B Puddey, Richard J Woodman, Jonathan M Hodgson
American Journal of Clinical Nutrition 2015 102(2):368–375

Bibliography

PubMed
PMID 26135348
Funding
Not yet independently verified in full text
Competing interests
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Study snapshot

DesignRandomized double-blind placebo-controlled crossover trial
ModelAdults with treated hypertension
Sample27 participants
InterventionOne-week nitrate-rich beetroot juice versus nitrate-depleted juice
DurationOne week per intervention
EndpointsHome blood pressure; 24-hour ambulatory blood pressure; Salivary, plasma and urinary nitrate and nitrite

What the study showed, in plain terms

In people already treated for hypertension, one week of beetroot juice increased nitrate-related biomarkers without lowering home or ambulatory blood pressure compared with placebo.

Key findings

Substantial plasma and salivary nitrate/nitrite increases; no significant improvement in home or 24-hour ambulatory blood pressure.

What this study can and cannot tell us

Small sample and short duration, but valuable counterevidence to universal blood-pressure efficacy claims.

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Editorial review

Reviewed by the Biohack Blueprint research team

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