This is the foundational spermidine-autophagy longevity paper. Spermidine extended lifespan in yeast, flies and worms, reduced oxidative damage in aging mice and induced autophagy across multiple systems including human cells.
Key findings
Autophagy was required for much of the longevity effect in model organisms. The paper established a mechanism, not evidence that spermidine extends human lifespan.
What this study can and cannot tell us
Human work was cellular, not a clinical intervention. Lifespan extension occurred in model organisms and cannot be extrapolated directly to people.
