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Vitamin D3 and calcium to prevent hip fractures in elderly women

M C Chapuy, M E Arlot, F Duboeuf, J Brun, B Crouzet, S Arnaud, P D Delmas, P J Meunier
The New England journal of medicine 1992 327(23):1637-42

Bibliography

PubMed
PMID 1331788
DOI
10.1056/NEJM199212033272305
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignHuman clinical research
ModelHuman participants
Sample3,270 ambulatory older women; mean age 84 years
InterventionVitamin D3 800 IU/day plus 1,200 mg/day elemental calcium, versus double placebo
Duration18 months
EndpointsHip and other nonvertebral fractures; Vitamin D and parathyroid hormone; Femoral bone density

What the study showed, in plain terms

This publication examines hip and other nonvertebral fractures, vitamin d and parathyroid hormone, femoral bone density. Study population or evidence base: 3,270 ambulatory older women; mean age 84 years. Intervention or exposure: Vitamin D3 800 IU/day plus 1,200 mg/day elemental calcium, versus double placebo.

Key findings

Combined calcium and D3 reduced hip and other nonvertebral fractures in this older female population, while improving vitamin D status and suppressing secondary hyperparathyroidism.

What this study can and cannot tell us

The benefit concerns calcium plus D3 in a particular elderly population. It does not isolate vitamin D's effect or establish equivalent fracture protection from D3/K2/magnesium without calcium.

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