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Effect of vitamin D supplementation alone on muscle function in postmenopausal women: a randomized, double-blind, placebo-controlled clinical trial

L M Cangussu, J Nahas-Neto, C L Orsatti, F N Bueloni-Dias, E A P Nahas
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2015 26(10):2413-21

Bibliography

PubMed
PMID 25956283
DOI
10.1007/s00198-015-3151-9
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignRandomized controlled clinical trial
ModelHuman participants
Sample160 postmenopausal women aged 50–65 with a history of falls
InterventionVitamin D3 1,000 IU/day or placebo
Duration9 months
EndpointsLower-limb and grip strength; Lean mass; Vitamin D status

What the study showed, in plain terms

This publication examines lower-limb and grip strength, lean mass, vitamin d status. Study population or evidence base: 160 postmenopausal women aged 50–65 with a history of falls. Intervention or exposure: Vitamin D3 1,000 IU/day or placebo.

Key findings

Vitamin D improved lower-limb strength and helped preserve lean mass in this population with low starting vitamin D levels.

What this study can and cannot tell us

A selected group of postmenopausal women with previous falls. These findings should be distinguished from the largely neutral muscle results in broader, less-deficient trial populations.

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