Tier 1 — highest

Vitamin D and Muscle Health: A Systematic Review and Meta-analysis of Randomized Placebo-Controlled Trials

Lise Sofie Bislev, Diana Grove-Laugesen, Lars Rejnmark
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2021 36(9):1651-1660

Bibliography

PubMed
PMID 34405916
DOI
10.1002/jbmr.4412
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignSystematic review and meta-analysis
ModelHuman evidence synthesis
Sample54 randomized trials involving 8,747 participants
InterventionVitamin D2 or D3, with differing schedules and optional calcium
DurationVaried across included trials
EndpointsMuscle strength; Physical performance; Lean mass

What the study showed, in plain terms

This publication examines muscle strength, physical performance, lean mass. Study population or evidence base: 54 randomized trials involving 8,747 participants. Intervention or exposure: Vitamin D2 or D3, with differing schedules and optional calcium.

Key findings

Vitamin D did not improve overall muscle-health measures; some pooled performance or strength measures were slightly less favorable than placebo.

What this study can and cannot tell us

Doses, populations and schedules varied. The synthesis does not directly answer treatment of severe symptomatic deficiency or specific combined nutrient regimens.

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