Ca-AKG vs AKG: does the calcium binding really matter?
Ca-AKG vs free AKG: both have human oral data, but no clean head-to-head trial proves a dramatic Ca-AKG bioavailability advantage. What differs is salt chemistry, calcium exposure and...
Evidence library 24 analyses
Ca-AKG
A research hub for calcium alpha-ketoglutarate (Ca-AKG): longevity biology, human evidence, dosing, formulations and safety.
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All Ca-AKG analysis
Browse every published guide, review and evidence update in this topic.
Ca-AKG vs AAKG: which one, and why they're different
Ca-AKG vs AAKG: calcium versus arginine salts, mixed AAKG exercise trials, the distinct Ca-AKG aging evidence base, and why the two are not interchangeable.
How does Ca-AKG work? Mechanisms explained
How Ca-AKG works: the TCA cycle, TET/JmjC enzymes, ATP synthase/TOR, AMPK, immune signaling, senescence, OXGR1 and the conflicting autophagy evidence.
What is Ca-AKG supplement? A plain-English guide
What is Ca-AKG? A plain-English guide to calcium alpha-ketoglutarate, what AKG does in the body, why it is sold for longevity, and what it is not.
Shahmirzadi 2020 Ca-AKG study: what it found and what replication changed
Shahmirzadi 2020 explained in light of 2026 evidence: female lifespan and frailty findings, SASP and IL-10 biology, the invalid mouse-to-human dose shortcut, and two null NIA ITP replications.
Calcium alpha-ketoglutarate: benefits, dose and evidence
Calcium alpha-ketoglutarate (Ca-AKG) reviewed against 63 audited papers: benefits, dose, safety, biological age, mixed mouse lifespan results and what remains unproven.