Tier 3 — preclinical
Balance between DNA repair, LINE1 suppression and lifespan in mice with SIRT6 Serine 10 phosphorylation site mutations
bioRxiv
2026
Preprint
Bibliography
- PubMed
- PMID 41676543
Study snapshot
| Design | Genetically engineered mouse study comparing phospho-null S10A and phosphomimetic S10E SIRT6 mutants with wild-type controls. |
|---|---|
| Model | SIRT6 Ser10 mutant mice and associated molecular assays. |
| Sample | Mouse lifespan cohorts; exact group sizes reported in the preprint. |
| Intervention | Constitutive SIRT6 Ser10 phospho-null or phosphomimetic mutation. |
| Duration | Lifespan study. |
| Endpoints | Lifespan; DNA repair capacity; LINE1 expression; SIRT6 recruitment to DNA damage |
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