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Effects of Collagen Supplements on Skin Aging: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
The American Journal of Medicine
2025
138(9):1264–1277
Bibliography
- PubMed
- PMID 40324552
- Funding
- The 2025 paper reports no external funding.
- Competing interests
- Authors declared no conflicts of interest.
Study snapshot
| Design | Meta-analysis of 23 randomized controlled trials; prespecified subgroup analyses by funding and study quality |
|---|---|
| Model | Adults receiving oral collagen or placebo in skin-aging RCTs |
| Sample | 23 RCTs; 1,474 participants |
| Intervention | Mixed oral collagen supplements vs controls; multiple products and sources |
| Duration | Varied among the 23 RCTs |
| Endpoints | Skin hydration; Skin elasticity; Wrinkles; Industry funding and study-quality sensitivity |
What the study showed, in plain terms
Key findings
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