Tier 2 — strong
Ingestion of β-nicotinamide mononucleotide increased blood NAD levels, maintained walking speed, and improved sleep quality in older adults in a double-blind randomized, placebo-controlled study
GeroScience
2024
46(5):4671-4688
Bibliography
- PubMed
- PMID 38789831
- PubMed Central
- PMC11336149
- Funding
- The study was funded by Meiji Holdings Co., Ltd.
- Competing interests
- Masashi Morifuji, Seiichiro Higashi and Masashi Nagata were employees of Meiji Holdings Co., Ltd.
Study snapshot
| Design | Randomized, double-blind, placebo-controlled parallel-group trial. |
|---|---|
| Model | Healthy older adults aged approximately 65–75 years. |
| Sample | n=60; 30 NMN and 30 placebo. |
| Intervention | β-NMN 250 mg/day versus placebo. |
| Duration | 12 weeks. |
| Endpoints | Primary stepping test; 4-m walking time; Blood NAD+ and metabolites; Pittsburgh Sleep Quality Index; Stress/questionnaire outcomes; Safety |
What the study showed, in plain terms
Key findings
What this study can and cannot tell us
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