Tier 3 — preclinical
Long-lived mammals contain more phosphorylation sites in the SIRT6 C-terminus that enhance PARP1 interaction and resistance to oxidative stress
GeroScience
2026
Online ahead of print
Bibliography
- PubMed
- PMID 42417966
- Funding
- NIH/NIA grants AG047200 and AG027237.
- Competing interests
- Vera Gorbunova is a scientific advisory board member for DoNotAge, Genflow Bio, Elysium and WndrHealth. Other authors declared no competing interests.
Study snapshot
| Design | Comparative proteomics across mammalian species plus biochemical, in silico and human fibroblast mutation experiments. |
|---|---|
| Model | SIRT6 proteins across mammalian species; human fibroblasts carrying phospho-null or phospho-mimetic SIRT6 T294 variants. |
| Sample | Multiple mammalian species and cell experiments; exact sample counts vary by experiment. |
| Intervention | Comparative SIRT6 phosphorylation profiling and T294A/T294E mutagenesis. |
| Duration | Experimental; not a longitudinal treatment study. |
| Endpoints | SIRT6 C-terminal phosphorylation; Maximum species lifespan correlation; PARP1 interaction; Oxidative-stress survival |
What the study showed, in plain terms
Key findings
What this study can and cannot tell us
Citation network
Articles citing this research paper
Biohack Blueprint analyses that reference this study in their evidence base.
- SIRT6 Activator Benefits: What the Evidence Actually ShowsSIRT6 activator benefits are strongest for DNA repair and other mechanistic pathways, with mouse evidence for longevity and metabolism. Human anti-aging benefits...Read analysis
- SIRT6 Mechanism & Structure: Catalytic Activities, Regulation and ActivatorsSIRT6 has one active site and three distinct enzymatic activities. Here's how the enzyme is built, how it works, and what activators...Read analysis
- SIRT6 and DNA Repair: DSB Sensing, PARP1, BER & TelomeresRead analysis
- SIRT6 Longevity: Mouse Lifespan, Human Evidence & What Is ProvenRead analysis
- What Is SIRT6? Function, Aging, DNA Repair & Human EvidenceSIRT6 is an NAD+-dependent nuclear enzyme involved in DNA repair, chromatin, metabolism and aging. Mouse studies show lifespan effects; human studies now...Read analysis
Editorial review
Reviewed by the Biohack Blueprint research team
Last verified
