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Efficacy and safety of hydrolyzed collagen supplementation on skin health outcomes: a systematic literature review of randomized controlled trials
European Journal of Clinical Nutrition
2026
80(9):867–885
Bibliography
- PubMed
- PMID 42342959
- Funding
- No explicit funding statement was located in the accessible publisher/PubMed records reviewed on 2026-09-23.
- Competing interests
- M.S. reported employment by Lumanity and stated that he had no conflicts of interest specifically related to this review.
Study snapshot
| Design | Systematic literature review with Cochrane RoB 2; searched through April 1, 2023 |
|---|---|
| Model | Adult participants, primarily healthy volunteers; some OA or RA cohorts |
| Sample | 25 RCTs; per-trial enrollment 13–236; overlapping populations across earlier reviews |
| Intervention | Oral hydrolysed collagen vs placebo or active comparators |
| Duration | Varied |
| Endpoints | Skin hydration; Skin elasticity; Wrinkles; TEWL; Safety and quality of life |
What the study showed, in plain terms
Key findings
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Citation network
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- Collagen for Skin: Do Hydrolysed Collagen Peptides Help?Several trials report improvements in skin hydration, elasticity or wrinkles, but newer funding- and quality-sensitive reviews lower confidence. Here’s the full evidence.Read analysis
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- Hydrolysed Collagen Peptides: Benefits, Dosage, Safety & EvidenceA complete evidence-graded guide to hydrolysed collagen peptides: what human studies suggest for skin, joints and bone, where evidence is uncertain, plus...Read analysis
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