Evidence library 26 analyses
A fisetin evidence hub covering senolytic research, human trials, bioavailability, dosing, safety and supplement quality.
Complete library
Browse every published guide, review and evidence update in this topic.
Human fisetin studies have not shown a consistent severe-toxicity signal, but the safety database remains small and heterogeneous. Long-term routine use, medication interactions and safety in pregnancy, cancer...
Strawberries led an influential historical fisetin food analysis, but its widely quoted 160 µg/g figure comes from freeze-dried, acid-hydrolyzed samples—not a validated fresh-fruit dose. Compare the original food...
Liposomal fisetin has a plausible delivery rationale, but clinical absorption and outcome advantages remain unproven for commercial products. A 2025 cell study found senomorphic effects from both free...
A small human crossover study found greater dose-adjusted fisetin plasma exposure with a specific hybrid-hydrogel formulation than with unformulated fisetin. Neither result establishes a human senolytic concentration or...
Fisetin is studied for senotherapeutic effects; urolithin A targets mitophagy. Urolithin A has the more developed human intervention literature, while human systemic senescent-cell clearance with fisetin remains unproven....
Fisetin is studied as a candidate senolytic, while spermidine is studied for autophagy-related biology. Their mechanisms and human evidence are different, and no controlled trial has shown that...
Fisetin and quercetin are related flavonols with overlapping preclinical senotherapeutic biology, but their human evidence differs. Fisetin has stronger preclinical senolytic activity in some models; quercetin has a...
No veterinary clinical trial has established fisetin's safety, efficacy or dose in dogs or cats. Animal and human research should not be converted into pet dosing by body-weight...
There are no adequate safety data for concentrated fisetin supplements during pregnancy or breastfeeding. Ordinary fruit eaten as part of a pregnancy-appropriate diet is a different exposure; it...
