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Serum SIRT6 Levels Are Associated with Frailty in Older Adults

M Zhu, X Yang, Y Huang, Z Wang, Z Xiong
The Journal of Nutrition, Health & Aging 2023 27(9):719-725

Bibliography

PubMed
PMID 37754211
PubMed Central
PMC12275554
DOI
10.1007/s12603-023-1969-y
Funding
Supported by the National Key Research and Development Program of China (2018YFC2002000).
Competing interests
The authors reported no conflicts of interest.

Study snapshot

DesignCross-sectional study of serum SIRT6 and frailty-phenotype components.
ModelCommunity-dwelling and outpatient adults aged 65 years or older in Wuhan, China.
Sample540 participants.
InterventionNo intervention.
DurationCross-sectional.
EndpointsSerum SIRT6; frailty status; slowness; weakness; exhaustion; ROC discrimination

What the study showed, in plain terms

Among 540 adults aged 65 or older, lower serum SIRT6 was associated with frailty and several frailty components including slowness, weakness and exhaustion.

Key findings

Serum SIRT6 was lower in several frailty-component groups, and multivariable analysis found an independent association between lower SIRT6 and frailty.

What this study can and cannot tell us

Cross-sectional design prevents causal inference. The ELISA biomarker is not a treatment-selection tool, and no SIRT6 activator was tested.

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Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability