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Age-related changes of human serum Sirtuin6 in adults

Ying Zhao, Xiangli Bai, Xiong Jia, Yajing Lu, Wenzhuo Cheng, Meng Shu, Yan Zhu, Lin Zhu, Li Wang, Yan Shu, Yi Song, Si Jin
BMC Geriatrics 2021 21(1):452

Bibliography

PubMed
PMID 34348649
PubMed Central
PMC8335874
DOI
10.1186/s12877-021-02399-0
Funding
National Natural Science Foundation of China grants 82070862 and 81901675.
Competing interests
The authors declared no competing financial interests.

Study snapshot

DesignCross-sectional age-stratified human biomarker study with serum ELISA and vascular tissue analyses.
ModelHealthy adults aged 20-30, 45-55 and at least 70 years.
Sample155 participants.
InterventionNo intervention; age-group comparison.
DurationCross-sectional.
EndpointsSerum SIRT6; serum telomerase; vascular SIRT6/hTERT expression; correlation with age

What the study showed, in plain terms

In 155 healthy adults, serum SIRT6 and telomerase levels were lower at older ages. Serum SIRT6 correlated negatively with age and positively with telomerase.

Key findings

Serum SIRT6 correlated negatively with age (r=-0.5830) and positively with telomerase (r=0.5743) in this cross-sectional sample.

What this study can and cannot tell us

The study is cross-sectional, cannot establish causation, and serum SIRT6 is not yet a validated clinical aging biomarker or treatment target.

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability