Tier 3 — preclinical
SIRT6 promotes intrahepatic cholangiocarcinoma development by reprogramming glutamine metabolism via enhanced GLUL
Gut
2026
75(7):1383-1396
Bibliography
- PubMed
- PMID 41136182
Study snapshot
| Design | Spatial/single-cell human tumor analysis plus mechanistic cell experiments and allograft/primary mouse ICC models. |
|---|---|
| Model | Human intrahepatic cholangiocarcinoma samples and datasets, ICC cell lines, allografts and AKT/YAP-induced primary ICC mice. |
| Sample | Multiple clinical datasets/specimens and mouse experiments; exact totals vary by analysis. |
| Intervention | SIRT6 knockdown/overexpression and SIRT6 or GLUL inhibition. |
| Duration | Model-specific experimental durations. |
| Endpoints | Tumor growth; SIRT6 expression; GLUL transcription and protein stability; Glutamine synthesis; Nucleotide and amino-acid levels; Chemotherapy sensitivity |
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