Tier 4 — mechanistic

A comprehensive view on the fisetin impact on colorectal cancer in animal models: Focusing on cellular and molecular mechanisms

Zamanian MY, Taheri N, Ramadan MF, Mustafa YF, Alkhayyat S, Sergeevna KN, Alsaab HO, Hjazi A, Molavi Vasei F, Daneshvar S
Animal Models and Experimental Medicine 2024 7(5):591-605

Bibliography

PubMed
PMID 39136058
PubMed Central
PMC11528395
DOI
10.1002/ame2.12476
Funding
Not stated in the reviewed abstract/metadata.
Competing interests
Not stated in the reviewed abstract/metadata.

Study snapshot

DesignNarrative literature review summarising fisetin's cellular and molecular mechanisms against colorectal cancer in animal and cell-culture models, including a background section on dietary sources and content of fisetin in foods.
ModelNot applicable — narrative review, not primary research.
SampleNot applicable.
InterventionNot applicable — review of fisetin's effects on colorectal cancer cell signalling (p53, Wnt/EGFR/NF-κB, PI3K/Akt/mTOR pathways) in prior animal and cell-culture studies.
DurationNot applicable.
EndpointsNarrative summary of fisetin's effects on colorectal cancer cell apoptosis, proliferation and signalling pathways; Background dietary source and food-content summary for fisetin

What the study showed, in plain terms

This is a review article pulling together what's known about how fisetin affects colorectal cancer cells in animal and lab studies, rather than a new experiment of its own.

As background, the authors summarise where dietary fisetin comes from, reporting that strawberries have the highest measured fisetin content at 160 µg per gram, with apples and persimmons carrying smaller amounts (26.9 and 10.5 µg per gram respectively), alongside other sources such as onions, kiwifruit and grapes.

Bottom line: cited here specifically for its dietary fisetin-content figures, which are among the few peer-reviewed, quantified numbers available for how much fisetin specific foods contain.

Key findings

Reports fisetin content of 160 µg/g in strawberries, 26.9 µg/g in apples, and 10.5 µg/g in persimmons, citing prior food-composition literature; the review itself otherwise summarises fisetin's mechanistic anticancer effects in colorectal cancer models (apoptosis induction via p53, inhibition of Wnt/EGFR/NF-κB and PI3K/Akt/mTOR signalling).

What this study can and cannot tell us

A narrative review, not primary research — the dietary fisetin-content figures are drawn from the review's own cited sources rather than original measurement, and the review does not provide a full breakdown of fisetin content across the other foods it names (onions, kiwifruit, grapes).

Citation network

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Editorial review

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology