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Effects of Ingesting Fucoidan Derived from Cladosiphon okamuranus Tokida on Human NK Cells: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Pilot Study

Makoto Tomori, Takeaki Nagamine, Tomofumi Miyamoto, Masahiko Iha
Marine Drugs 2021 19(6):340

Bibliography

PubMed
PMID 34203925
PubMed Central
PMC8232719
Funding
The research and article-processing charge were funded by South Product.
Competing interests
Makoto Tomori and Masahiko Iha received compensation from South Product; the Okinawa mozuku fucoidan test material was supplied by South Product.

Study snapshot

DesignRandomized double-blind parallel-group placebo-controlled pilot trial
ModelHealthy middle-aged adults
Sample40 participants (20 fucoidan, 20 placebo)
InterventionCladosiphon okamuranus fucoidan 3.0 g/day in beverage versus placebo
Duration12 weeks
EndpointsNatural killer cell activity; Blood counts; Biochemistry; Immunological measures; Adverse events

What the study showed, in plain terms

Healthy adults consumed 3 g/day of Okinawa mozuku fucoidan for 12 weeks. The trial found no clinically adverse test-food events and reported an NK-cell activity signal at week 8, especially in men. It supports human repeated-dose tolerability and immune plausibility for fucoidan as a class, not SIRT6 activation by the DoNotAge formulation.

Key findings

No clinically adverse events attributed to the test food were reported.

NK-cell activity increased from baseline at week 8 in the fucoidan group.

A between-group NK-cell signal was reported in male participants at week 8.

What this study can and cannot tell us

Small pilot sample.

Sex-subgroup finding increases uncertainty.

Cladosiphon-derived fucoidan differs from Fucus-derived SIRT6Activator.

Industry funding and author compensation were disclosed.

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