Tier 3 — preclinical
Macrophage SIRT6 promotes allergic airway inflammation through ATG3 deacetylation-mediated autophagy
Mucosal Immunology
2026
19(3):100335
Bibliography
- PubMed
- PMID 41864241
- Competing interests
- Authors declared no known competing financial interests or personal relationships.
Study snapshot
| Design | Murine allergic-airway-inflammation study with myeloid-specific Sirt6 deletion and macrophage mechanistic experiments. |
|---|---|
| Model | Asthmatic mice and macrophages. |
| Sample | Multiple animal and cellular experiments; exact group sizes not stated in indexed abstract. |
| Intervention | Myeloid Sirt6 deletion and OSS-128167 pharmacological SIRT6 inhibition. |
| Duration | Model-specific. |
| Endpoints | Airway inflammation; Pro-inflammatory cytokines; ATG3 K77 deacetylation; Autophagy; Response to SIRT6 inhibition |
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