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Absorption Study of Mozuku Fucoidan in Japanese Volunteers

Kizuku Kadena, Makoto Tomori, Masahiko Iha, Takeaki Nagamine
Marine Drugs 2018 16(8):254

Bibliography

PubMed
PMID 30061499
PubMed Central
PMC6117716
Funding
The authors reported no external funding.
Competing interests
The authors declared no conflict of interest. Three authors were affiliated with South Product Co., Ltd.

Study snapshot

DesignHuman oral administration and absorption study
ModelJapanese adult volunteers
Sample396
InterventionSingle oral 3 g dose of mozuku fucoidan with urine collection at 0, 3, 6 and 9 hours
Duration9-hour post-dose sampling
EndpointsUrinary fucoidan detection; Estimated fucoidan excretion; Association with habitual mozuku intake; Regional differences in absorption

What the study showed, in plain terms

This large human absorption study challenges the idea that orally consumed fucoidan is never absorbed. After 3 g of mozuku fucoidan, urinary fucoidan was detectable in most participants. It demonstrates human exposure, not delivery of a Fucus-derived polymer to nuclear SIRT6.

Key findings

Fucoidan was detected after ingestion in 385 of 396 participants.

Absorption/excretion varied substantially between individuals.

Habitual mozuku consumption and Okinawan residence were associated with higher measured urinary fucoidan.

What this study can and cannot tell us

Urinary detection does not establish intact intracellular delivery to SIRT6.

The tested fucoidan came from Cladosiphon okamuranus, not the Fucus material used in SIRT6 studies.

This was not a randomized efficacy trial.

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