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Investigating fucoidan blend supplementation and resistance training in humans: a parallel randomized controlled trial design

Stephen D Cousins, Samantha T C Kucewicz, Daniel W T Wundersitz, Blake E G Collins, Matthew B Cooke, Nicola McKeown, Hericka B Figueiredo Galvao, Stephanie M Resciniti, Phil M Lyristakis, Brett A Gordon, Chris van der Poel
Scientific Reports 2025 15(1):40249

Bibliography

PubMed
PMID 41249370
PubMed Central
PMC12624114
Trial registry
View on ClinicalTrials.gov Registered trial — results not yet published in a peer-reviewed journal.
Funding
Supported by Marinova Pty Ltd, which also produced and supplied the fucoidan blend.
Competing interests
The authors declared no competing interests.

Study snapshot

DesignSix-week randomized double-blind placebo-controlled parallel trial with supervised resistance training
ModelApparently healthy adults completing resistance training
Sample20 participants (10 fucoidan, 10 placebo)
Intervention1 g/day fucoidan blend containing Undaria pinnatifida and Fucus vesiculosus versus microcrystalline-cellulose placebo during resistance training
Duration6 weeks
Endpoints1RM back squat; Wingate peak power; Lean body mass; Body fat percentage; Blood measures

What the study showed, in plain terms

This small 2025 RCT combined 1 g/day of a Fucus/Undaria fucoidan blend with resistance training. Back-squat strength improved in both groups without a significant treatment effect; selected anaerobic-power and body-composition outcomes favored the fucoidan group. It offers human muscle/functional data, but it cannot be treated as direct evidence for SIRT6 activation.

Key findings

No significant fucoidan treatment effect on the primary back-squat strength change.

Peak and relative peak power improved within the fucoidan group.

A treatment effect was reported for body composition, with increased lean mass and reduced body-fat percentage in the fucoidan group.

What this study can and cannot tell us

Only 20 participants.

Multiple outcomes and short duration increase uncertainty.

The product was a mixed Undaria/Fucus blend rather than DoNotAge SIRT6Activator.

Marinova funded the study and supplied the formulation.

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