Tier 1 — highest

Effects of L-citrulline supplementation on blood pressure: A systematic review and meta-analysis

Bahareh Barkhidarian, Masoud Khorshidi, Sakineh Shab-Bidar, Baran Hashemi
Avicenna Journal of Phytomedicine 2019 9(1):10–20

Bibliography

PubMed
PMID 30788274
PubMed Central
PMC6369322
Funding
Not yet independently verified for this record
Competing interests
Not yet independently verified for this record

Study snapshot

DesignSystematic review and random-effects meta-analysis
ModelAdult participants in eight randomized L-citrulline blood-pressure studies (primary samples 12–34)
SampleEight randomized trials; ten datasets; 12–34 participants per primary trial
InterventionOral L-citrulline versus control
DurationVaried across eight primary randomized trials
EndpointsSystolic and diastolic blood pressure

What the study showed, in plain terms

Reported a pooled systolic blood-pressure reduction, while pooled diastolic evidence was less consistent.

Key findings

Reported a pooled systolic blood-pressure reduction, while pooled diastolic evidence was less consistent.

What this study can and cannot tell us

Small underlying studies; overlapping primary studies with Mirenayat 2018 must not be double-counted.

Citation network

Articles citing this research paper

2 articles

Biohack Blueprint analyses that reference this study in their evidence base.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified