Tier 4 — mechanistic
Evaluation of AppleX™ Apple Extract on Anti-Inflammatory and Healthy Aging Effects
ClinicalTrials.gov trial registry record
2026
Bibliography
- Trial registry
- View on ClinicalTrials.gov Registered trial — results not yet published in a peer-reviewed journal.
- Funding
- Industry-sponsored by Nutraland USA, Inc.; Alethios, Inc. is listed as a collaborator.
- Competing interests
- Registry record; no manuscript-level conflict-of-interest statement is available. The study is industry-sponsored and tests the sponsor's proprietary apple extract.
Study snapshot
| Design | Randomized, triple-masked, placebo-controlled parallel pilot study. |
|---|---|
| Model | Adults aged 45-70 years with low-grade systemic inflammation enrichment. |
| Sample | Estimated enrollment: 70 participants. |
| Intervention | AppleX whole-apple extract, 100 mg once daily with breakfast for 24 weeks, standardized to 15% fisetin and containing a polyphenol matrix that also includes quercetin, chlorogenic acid and procyanidins, versus placebo. |
| Duration | 24 weeks. |
| Endpoints | High-sensitivity CRP; Vitality and energy; Fatigue; Joint comfort; Exploratory epigenetic aging metrics |
What the study showed, in plain terms
Key findings
What this study can and cannot tell us
Citation network
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- Fisetin Senolytic: Does It Clear Senescent Cells in Humans?Fisetin is clearly senolytic in some experimental cell systems and strongly senotherapeutic in animals, but controlled proof of systemic senescent-cell clearance in...Read analysis
- Fisetin Benefits: What the Evidence Actually ShowsFisetin has strong preclinical evidence as a senotherapeutic, but human findings remain early and mixed. This evidence review separates randomized trials, human...Read analysis
- Fisetin Dosage: What Human Studies Actually UseThere is no single established fisetin dose. Human studies have used 100 mg/day, 200–800 mg/day, 2 mg/kg intermittent dosing, ~20 mg/kg senolytic...Read analysis
- Fisetin for Inflammation and Joint Pain: The Evidence (2026)Fisetin has broad preclinical anti-inflammatory activity, but human evidence is mixed. Small trials report selected biomarker changes, while the completed knee-osteoarthritis trial...Read analysis
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